NEW YORK (GenomeWeb) – Researchers in the lab of Johns Hopkins University professor Bert Vogelstein have identified a pair of potential peptide biomarkers for ovarian cancer.
Described in a study published this week in Proceedings of the National Academy of Sciences, the markers stem from efforts by the lab, which had traditionally focused on cancer genomics, to move more seriously into the proteomic and protein biomarker space, said Qing Wang, a faculty member in Vogelstein’s lab and first author on the study.
The peptide markers were validated using a selected-reaction monitoring system developed by Wang and his colleagues that uses light-labeled peptides and extensive fractionation to enable highly sensitive and reproducible quantitation of candidate biomarkers in plasma.
